The Worst Thing About My Sister focuses on the classic sibling rivalry between two very different sisters, Marti and Melissa. Marti is a tomboyish, adventurous girl who loves skateboarding and is fiercely competitive. Melissa is a stereotypical girly-girl, obsessed with fashion, makeup, and pink. The story is told through Marti's point of view, detailing her intense frustration with her sister's constant intrusion into her life and her inability to understand her interests. The book humorously and honestly explores the challenges of sharing a room, dealing with different personalities, and the underlying, enduring love that connects two siblings despite their differences.