Best Friends is a warm, relatable novel about the intense and sometimes challenging bond between two girls, Alice and Gemma, who have been inseparable since birth. Their lives are entwined because their mothers are also best friends. The narrative follows the girls as their friendship is put to the ultimate test when Alice's family decides to move away to Scotland. The story explores the pain of separation, the struggle to maintain a long-distance relationship, and the natural evolution of friendships as children grow older and their interests change. Wilson captures the emotional intensity of pre-teen relationships, emphasizing the importance of loyalty and the difficulty of letting go.